Friday, July 31, 2026

The Obtain: Montana’s new experimental drug guidelines


That is at this time’s version of The Obtain, our weekday e-newsletter that gives a day by day dose of what’s happening on the planet of know-how.

Montana’s plan to change into an experimental medical hub simply pushed ahead 

As of this week in Montana, biotech corporations whose medicine have been by way of preliminary testing—typically in as few as 10 wholesome individuals—will pay $12,500 to use to a newly established overview board for approval.

As soon as its remedy is rubber-stamped, the corporate can promote it by way of experimental remedy clinics, the primary of which is more likely to be up and operating across the finish of this 12 months.   

Montana’s newest right-to-try laws is exclusive. Entry to medicine is theoretically obtainable to anybody who provides knowledgeable consent and will pay. For some, particularly individuals within the longevity neighborhood, that’s a hopeful and thrilling prospect. However to others, it’s unethical and harmful. 

Learn our story to find out about the place this will likely all be headed. 

—Jessica Hamzelou

Montana’s new “proper to strive” regulation can’t come quickly sufficient for some 

Kris DeVault is determined.

His son, Brody, born in March 2023, has one thing known as creatine transporter deficiency—a uncommon situation during which the mind and muscle mass lack the vitality they should develop.

There aren’t any cures for Brody’s situation. However DeVault has realized of an organization creating a drug which may assist. That drug remains to be within the early levels of improvement and has solely been examined in animals and a small variety of wholesome adults. Docs can’t prescribe it.

DeVault is aware of the drug won’t work. However he’s doing all he can to entry it regardless. Learn our story about DeVault’s efforts. 

—Jessica Hamzelou

This story is from The Checkup, our weekly biotech e-newsletter. Join to obtain it in your inbox each Thursday.

The must-reads

I’ve combed the web to search out you at this time’s most enjoyable/essential/scary/fascinating tales about know-how.

1 Anthropic says its fashions hacked exterior organisations throughout testing
It was prompted to conduct a overview after comparable points at OpenAI. (TechCrunch
+ Inside OpenAI’s hack of Hugging Face. (New Yorker $)
+ OpenAI known as the Hugging Face assault unprecedented. However we’ve been right here earlier than. (MIT Expertise Overview)

2 Europe is bracing itself for an much more fiery future
International locations like France and Spain can count on regimes akin to these in California. (Nature $)
+ Even the UK is experiencing fires now, too. (Guardian)
+ El Niño is partly accountable for this 12 months’s grueling heatwaves. (Wired $)
+ District cooling may assist beat excessive warmth in cities. (New Scientist $)

3 Drone warfare is making the skies extra harmful
A deadly aircraft accident within the US this Might, brought on by a navy GPS jamming train, might sign what’s to return. (Wired$)
+ Zelensky requested Trump to safe Musk’s permission for the usage of Starlink to information drone strikes inside Russia this week. (The Atlantic $)

4 As Large Tech’s AI spending grows, so do the jitters
Amazon, Google, Meta and Microsoft are set to take a position $1.5 trillion into AI infrastructure. However who pays for it? (NYT $)
Are traders actually getting chilly ft concerning the AI increase? (FT $)
An AI-focused hedge fund simply imploded. (CNBC)

5 How China has modified the sovereign AI playbook
Kimi 3 from Moonshot makes forking out for costly US fashions appear silly. (Remainder of World)
+ The US is profitable on the innovative. However China dominates low-cost fashions. (CNBC)
May AI find yourself too low-cost to manage? (Vox $)

6 Google’s Gemini can now management a humanoid robotic
It was beforehand restricted to higher physique actions. Now, it will probably handle the whole vary of movement. (Bloomberg $)
These gig employees are coaching humanoid robots at residence. (MIT Expertise Overview)

7 Amazon says it’s discovered “catastrophically costly” AI price overruns
It’s removed from alone—and that’s why the “tokenmaxxing” pattern disappeared so rapidly. (FT $)

8 How a distant indigenous neighborhood constructed an excellent quick fiber community
It was a fancy, costly endeavor. Nevertheless it now outperforms Starlink. (IEEE Spectrum
Stratospheric web may lastly begin taking off this 12 months. (MIT Expertise Overview)

9 Meet Wikipedia’s most diligent editor
Steven Pruitt is unremarkable in some methods—but really superb in others. (New Yorker $)

10 Now you can report AI slop with a button on LinkedIn
The individuals have spoken. And they’re bored with studying bland nonsense. (404 Media)

Quote of the day

“It’s a shock, considering that simply an hour earlier I’d been in my room and every part… and now, there’s nothing left.”

—18-year-old Raphael Fohanno tells Reuters his response to wildfires destroying his mother and father’ home within the French city of Biscarrosse.

One Extra Factor

A few of the 750 experiences revealed by the OTA throughout its 23-year historical past.
GOVERNMENT PRINTING OFFICE VIA PRINCETON UNIVERSITY

Congress used to judge rising applied sciences. Let’s do it once more.

The US Workplace of Expertise Evaluation, an unbiased workplace created by Congress within the early Nineteen Seventies, produced some 750 experiences throughout its 23-year historical past, assessing applied sciences as diverse as digital surveillance, genetic engineering, and distant sensing from outer house. 

The workplace functioned like a debunking arm. It sussed out the snake oil. Its experiences noticed by way of the alluring gleam of overhyped applied sciences. 

Since its unceremonious defunding in 1995, perennial calls have gone out: Rouse the workplace from the lifeless! 

Learn our story about why, with advances in robotics, large information, and AI methods, these calls have taken on a brand new stage of urgency. 

—Peter Andrey Smith

We will nonetheless have good issues

A spot for consolation, enjoyable, and distraction to brighten up your day. (Bought any concepts? Drop me a line.)

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+  Meet Pumpkin, a chubby cat that’s in no temper to drop pounds.
+ Uncover what the animals close to you’re in all probability doing proper now at Nature This Week.
+ Woodworker extraordinaire Matt Thompson has put in a mannequin railroad that runs alongside his fence



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